Cell-Autonomous and -Nonautonomous Functions of LAR in R7 Photoreceptor Axon Targeting

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Cell-Autonomous and -Nonautonomous Functions of LAR in R7 Photoreceptor Axon Targeting

During Drosophila visual system development, photoreceptors R7 and R8 project axons to targets in distinct layers of the optic lobe. We show here that the LAR receptor tyrosine phosphatase is required in the eye for correct targeting of R7 axons. In LAR mutants, R7 axons initially project to their correct target layer, but then retract to the R8 target layer. This targeting defect can be fully ...

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The receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism.

Receptor protein tyrosine phosphatases (RPTPs) control many aspects of nervous system development. At the Drosophila neuromuscular junction (NMJ), regulation of synapse growth and maturation by the RPTP LAR depends on catalytic phosphatase activity and on the extracellular ligands Syndecan and Dally-like. We show here that the function of LAR in controlling R7 photoreceptor axon targeting in th...

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R7 PHOTORECEPTOR AXON TARGETING AND PRESYNAPTIC ASSEMBLY IN DROSOPHILA by SCOTT HOLBROOK A DISSERTATION

Original approval signatures are on file with the Graduate School and the University of Oregon Libraries. The development of a functional nervous system is paramount for the ability of animals to interact with their environments. Minor defects in nervous system function compromise the effectiveness of sensing and responding to stimuli. Severe defects in nervous system function often lead to ext...

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ژورنال

عنوان ژورنال: Neuron

سال: 2001

ISSN: 0896-6273

DOI: 10.1016/s0896-6273(01)00471-8